Cortisol is a lipid soluble molecule that plays an important role in many homeostatic processes. Do you think that cortisol will be able to pass through the cell membrane? Where are the receptors for cortisol likely to be found in the cell? Formulate a general rule for the location of receptors.

Because cortisol is a lipid soluble molecule it is able to pass through the cell membrane and enter the intracellular fluid. The receptors for cortisol are located inside the cell. As a general rule we can say that the receptors for watersoluble (peptide) hormones are located on the surface of the cell, and the receptors for lipid soluble hormones are located in the intracellular fluid.