What are the major differences in the aerobic and anaerobic metabolism of glucose?

*Aerobic metabolism is more efficient than anaerobic metabolism because it converts more of the energy available in the molecule to ATP. This requires more complete breakdown of the molecule and so the process takes longer.

** In order for glycolysis to continue the pyruvate must be removed. If sufficient oxygen is available will enter the Krebs cycle but if there is not enough oxygen available the pyruvate will be converted to lactate. This lowers the intracellular pH and decreases the activity of the enzymes. As result ATP production decreases and the cell fatigues.